It was news that no one saw coming.
No more than who is next?
BBC Sport takes a look at some of the early contenders – plus you can vote for who you think should take the Anfield hot seat.
An early favorite with the bookmakers and a manager who has been touted as Klopp’s successor one day.
The former Liverpool striker has impressed for Bayer Leverkusen this campaign, taking them to the top of the Bundesliga – four points ahead of Bayern Munich – after guiding them to the semi-finals of the Europa League in his first half.
The 42-year-old, who has a contract until 2026, has the German side playing big, attacking football and would be a popular choice among Liverpool fans.
Roberto de Zerbi
Of those currently in charge in the Premier League, Brighton boss Roberto de Zerbi appears to be the most likely to replace Klopp.
The 44-year-old Italian has impressed the Liverpool boss with his versatility after winning the Reds the league and FA Cup last season, as well as making it 3-3 at Anfield in his first game in charge of the Seagulls. .
De Zerbi led Brighton to seventh place last season, which saw the club qualify for European competition for the first time.
Now the manager of Paris St-Germain, the 53-year-old was the Spanish boss.
He left the position after being eliminated from the World Cup by Morocco in the last 16 in December 2022, after leading his country to the semi-finals of Euro 2020.
Enrique’s best time as a manager at a club level came with Barcelona. Between 2014 and 2017 he won the Champions League and led them to two La Liga titles, three Copas del Rey, a Super Cup, a Club World Cup and a Spanish Super Cup.
A name that will no doubt be associated with the job in the next few months.
The Liverpool legend, 43, is often tipped to be Klopp’s long-term successor – especially after leading Rangers to the Scottish Premiership title in 2021.
His success north of the border, however, began to bear fruit as manager of Aston Villa, before moving to Saudi Arabia’s Al-Ettifaq, with whom he has signed a new contract.
Liverpool’s deputy manager is also tipped to leave the club to become manager, but will he be forced to stay at Anfield as a boss?
The 41-year-old is a well-respected coach but his previous experience has not been successful with NEC in the Dutch second division – sandwiched between his two spells as Liverpool’s number two.
The former Bayern Munich boss, 36, took over as Germany manager last September but his contract runs until July 2024 and he will be available after this summer’s European Championship.
The pair previously shared the same assistant – Marc Kosicke – and Klopp described Nagelsmann as a “little horse” and a “great coaching talent”.
The former RB Leipzig boss won the Bundesliga in his first season at Bayern Munich, before being sacked.
Tottenham’s Australian boss was a big fan of Liverpool on the rise, leading Spurs to fifth in the Premier League this season and bringing an exciting brand of football to the club.
The 58-year-old previously led Celtic to the Scottish title during his tenure, as well as the last domestic campaign.
He is one of the longest-serving managers in Europe’s top five leagues having been with Atletico Madrid since 2011. He is regularly linked with top jobs whenever there is a vacancy but seems to be committed to the Spanish team.
The 53-year-old Argentine broke the records of Real Madrid and Barcelona to win La Liga twice in 2013-14 and 2020-21, as well as winning the Europa League in 2011-12 and 2017-18.
His most exciting performance would be a break from Klopp’s Liverpool’s attacking style.
The French legend, 51, is another top manager out of a job, although whether he is currently looking for another job is another story.
A World Cup and European Championship with his country as a footballer, he won the Champions League three times and La Liga twice as manager of Real Madrid.
Former Liverpool manager Rafael Benitez, who won the European Cup in 2005, still owns a house in Wirral where his family live. He currently manages La Liga outfit Celta Vigo.
Other top managers who have been out of a job include Antonio Conte, Jose Mourinho, Hansi Flick, Graham Potter, Joachim Low and Julen Lopetegui.
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